| Date | Opponent | Time / TV | UM Rank | Location | Result | MBN Coverage |
|---|---|---|---|---|---|---|
| 9/4 | Western Michigan | 12:00 / ESPN | NR/NR | Ann Arbor, MI | 47-14 | STAT-O, Photos |
| 9/11 | Washington | 8:00 / ABC | RV/RV | Ann Arbor, MI | 31-10 | STAT-O |
| 9/18 | Northern Illinois | 12:00 / BTN | 25/25 | Ann Arbor, MI | 63-10 | STAT-O, Photos |
| 9/25 | RUTGERS (HC) | 3:30 / ABC | 19/19 | Ann Arbor, MI | 20-13 | STAT-O, Photos |
| 10/2 | @ WISCONSIN | 12:00 / FOX | 14/14 | Madison, WI | 38-17 | STAT-O |
| 10/9 | @ NEBRASKA | 7:30 / ABC | 9/8 | Lincoln, NE | 32-29 | STAT-O |
| 10/23 | NORTHWESTERN | 12:00 / FOX | 6/6 | Ann Arbor, MI | 0-0 | - |
| 10/30 | @ #9/7 MICHIGAN ST. | 12:00 / FOX | -/- | East Lansing, MI | 0-0 | - |
| 11/6 | INDIANA | TBA / TBA | -/- | Ann Arbor, MI | 0-0 | - |
| 11/13 | @ #7/8 PENN ST. | TBA / TBA | -/- | University Park, PA | 0-0 | - |
| 11/20 | @ MARYLAND | TBA / TBA | -/- | College Park, MD | 0-0 | - |
| 11/27 | #5/5 OHIO ST. | 12:00 / FOX | -/- | Ann Arbor, MI | 0-0 | - |
Previous seasons: 2016, 2017, 2018, 2019, 2020